Good question. Almost every runner I've ever talked to agrees that the first mile or two of a run can be the most uncomfortable. The effect is often compounded if that first mile comes on the heels of a rest day. Basically, what's happening is you're forcing your engine to work aerobic state before it's had a chance to properly warm up anaerobic state.
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The first mile? It lies…
How to Overcome Crappy-First-Mile Syndrome | The Pursuit of Awesome
The first mile of a run or about the first ten minutes of any exercise sucks for everybody. Go easy on yourself in that first mile, though, and you can set yourself up for a great workout or race. So you step out of your car, or out your front door, and try to immediately keep up a minute-mile pace. It sucks, right? You hate your life.
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How to Overcome Crappy-First-Mile Syndrome
Miles are like crepes … the first one is always a disaster. For that reason, I tell my runners all the time to never trust the feeling of that first mile. Many of the running-related questions I field on a regular basis are related to this Crappy-First-Mile Syndrome.
I always feel accomplished at the end of a run. I love that running makes me strong and it gives me better endurance and defined calves. But, oh man, sometimes in the moment it just hurts. Other times, it feels okay, but I get bored as heck.